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Cellular immune responses to adenoviral antigens in baboons 12490 and 12497. Baboons were treated as indicated in Fig. 1 and Table 1. Both animals were sacrificed 4.5 months after Ad2hAATΔE1 infusion. Splenocytes were restimulated in vitro as described in Materials and Methods section to perform proliferation (A) and CTL (B) assays. Target cells were fibroblasts from skin biopsies of each animal infected with Ad2hAATΔE1 or uninfected. E/T ratio, effector:target ratio.
