Table 3.
% of cells in G2/M | |||||||
Cell line | Control | 4 h incub. | 6 h incub. | 16 h incub. | 20 h incub. | 24 h incub. | 48 h incub. |
VRL | |||||||
ECV304 | 22.5 ± 1.3 | 37.7 ± 1.7a | 45.4 ± 2.0a | 58.2 ± 4.3a | 53.9 ± 6.9a | 58.7 ± 6.5a | 46.4 ± 6.2 |
CAL-27 | 17.9 ± 1.0 | 33.3 ± 1.0a | 40.3 ± 1.6a | 66.9 ± 5.6a | 61.9 ± 3.9a | 64.3 ± 4.2a | 23.7 ± 3.0b |
MCF-7 | 18.1 ± 1.2 | 23.2 ± 1.0a | 27.8 ± 1.5a | 46.3 ± 3.6a * | 39.6 ± 2.0a * | 42.6 ± 2.6a | 36.6 ± 2.3* |
H292 | 18.2 ± 1.2 | 31.6 ± 3.6a | 46.8 ± 5.9a | 71.4 ± 1.7a | 64.8 ± 4.4a | 64.7 ± 7.5a | 60.4 ± 3.1 |
VFL | |||||||
ECV304 | 20.6 ± 1.4 | 32.7 ± 3.3a | 37.9 ± 3.1a | 64.1 ± 5.6a | 44.9 ± 7.3a | 48.7 ± 6.5a | 42.4 ± 3.5 |
CAL-27 | 17.1 ± 1.5 | 33.7 ± 2.4a | 40.9 ± 1.3a | 61.2 ± 1.2a | 63.0 ± 6.5a | 62.7 ± 5.3a | 21.3 ± 2.9b |
MCF-7 | 18.7 ± 0.9 | 25.5 ± 1.8a | 30.8 ± 2.2a | 59.7 ± 1.0a | 54.6 ± 3.2a | 48.7 ± 5.9a | 49.3 ± 2.9 |
H292 | 18.7 ± 1.1 | 37.8 ± 3.2a | 38.5 ± 4.1a | 65.4 ± 5.1a | 66.0 ± 4.5a | 69.4 ± 3.0a | 65.7 ± 1.8 |
Percentages of cells in the G2/M phase of the cell cycle: at different incubation times with VRL and VFL; mean ± standard error.
a p < 0.05 compared to control
b p < 0.05 compared to 24 h incubation
* p < 0.05 compared to the equitoxic VFL concentration