Table 5.

Percentages of cells in the polyploid cell cycle.

Cell line	Control	24 h	48 h	24+24	24+48
	Percentage of cells in S2
	VRL
ECV304	1.5 ± 0.2	5.5 ± 0.9a	18.5 ± 1.2a *	17.6 ± 2.3b	20.1 ± 0.9b
CAL-27	1.3 ± 0.1	5.6 ± 1.6	22.9 ± 1.5a	12.3 ± 1.4b	20.2 ± 0.9b
MCF-7	2.2 ± 0.5	2.9 ± 0.8	9.7 ± 3.9	4.4 ± 0.6	8.6 ± 0.5b
H292	1.4 ± 0.4	3.0 ± 1.0	7.9 ± 1.4a	3.4 ± 0.7	5.7 ± 0.9
	VFL
ECV304	1.3 ± 0.2	7.6 ± 1.3a	22.4 ± 0.8a	12.6 ± 1.1b	16.2 ± 0.6b
CAL-27	1.7 ± 0.5	4.3 ± 1.0	21.8 ± 1.4a	11.8 ± 0.7	21.8 ± 0.8b
MCF-7	2.0 ± 0.3	2.8 ± 1.0	8.8 ± 1.6a	5.2 ± 0.4	10.6 ± 1.1b
H292	1.0 ± 0.2	2.9 ± 0.5a	7.1 ± 0.9a	3.6 ± 1.2	4.5 ± 0.5
	Percentage of cells in (G2/M)2
	VRL
ECV304	0.3 ± 0.0	1.2 ± 0.2a	12.2 ± 1.5a	9.8 ± 1.6b	10.2 ± 1.3b
CAL-27	0.4 ± 0.1	2.2 ± 0.6	37.4 ± 4.8a	4.8 ± 0.5b	6.1 ± 0.9b
MCF-7	0.5 ± 0.1	1.3 ± 0.3	2.1 ± 0.5	2.1 ± 0.7	3.4 ± 0.2b
H292	0.3 ± 0.1	1.1 ± 0.3	6.5 ± 1.0a	1.4 ± 0.2	2.2 ± 0.2b
	VFL
ECV304	0.2 ± 0.0	0.8 ± 0.3	15.6 ± 0.8a	8.5 ± 1.3b	9.2 ± 1.1b
CAL-27	0.3 ± 0.1	2.1 ± 0.5	41.8 ± 4.9a	5.4 ± 0.4	7.5 ± 0.5b
MCF-7	0.5 ± 0.1	1.3 ± 0.2a	4.4 ± 0.8a	2.0 ± 0.5	4.4 ± 0.4b
H292	0.2 ± 0.0	1.2 ± 0.2a	7.0 ± 0.9a	1.9 ± 0.4	2.4 ± 0.3b

Percentages of cells in the polyploid cell cycle: at different incubation times with VRL or VFL and at different times after drug removal; mean ± standard error.

^a p < 0.05 compared to control

^b p < 0.05 compared to 24 h incubation

* p < 0.05 compared to equitoxic VFL conc.