Figure 1.
Amino acid sequence alignment of IKCa, rSK2, KcsA, and Shaker showing sequence similarities within the S6 transmembrane segment. The sequence alignment of the Pore + S6 region of IKCa, rSK2, KcsA, and Shaker was based on the conserved GYGD pore motif. Sequence similarities of 100% and 75% are shaded in black and gray, respectively. The S6 segment in IKCa is presented as extending from V266 to the A286.