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. 2002 Jul;120(1):99–116. doi: 10.1085/jgp.20028586

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Copyright © 2002, The Rockefeller University Press

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Figure 7. — Protection by MTSET of TEA block for the A283C and A286C mutants. (A) Inside-out current recording illustrating the blocking action of TEA (30 mM) on the wild-type IKCa channel. (B) Inside-out recording demonstrating the lack of TEA-dependent block with the A283C mutant after application of MTSET. (C) Inside-out recording illustrating the reduced effectiveness of TEA on the A286C mutant stimulated by MTSET. (D) Histogram summarizing the effects of TEA on the wild-type IKCa channel (WT), and on the A283C and A286C mutants activated by MTSET. WT channel was blocked at 79 ± 4% (n = 6), whereas the blocking effect of TEA was reduced to 6.5 ± 4.6% (n = 3) for the A283C + MTSET mutant and to 27 ± 7% (n = 3) for the A286 mutant stimulated by MTSET.