TABLE III.

TBA Block

	i	P o,max	k on	k off	K d
	pA		s−1M−1 (× 106)	s−1	μM
WT	1.16 ± 0.08 (n = 5)	0.85 ± 0.03	1.91	29.5	15.4
Y485C	0.63 ± 0.04 (n = 5)	0.78 ± 0.02	1.14	22.3	19.6
Y485S	0.66 ± 0.07 (n = 3)	0.71 ± 0.05	1.00	20.9	20.9
Y485A	0.55 ± 0.03 (n = 3)	0.52 ± 0.04	0.56	19.4	34.7
WT/Rb+	0.31 ± 0.02 (n = 3)	0.83 ± 0.01	1.72	51.1	29.7
Y485A/Rb+	0.28 ± 0.01 (n = 4)	0.79 ± 0.01	0.46	32.4	70.9