Table 1.
Mean pharmacokinetic parameters for radioactivity in plasma and whole blood for 300 mg oral solution dose (study 1)
| Parameter | Medium | Mean (% CV or SD) | Blood/plasma ratio (% CV) |
|---|---|---|---|
| AUCt (ng equiv g−1 h)* | Plasma | 4497 (4.6%) | nc |
| Blood | 2251 (45%) | 0.624 (24%)‡ | |
| Cmax (ng equiv g−1)* | Plasma | 800 (28%) | nc |
| Blood | 489 (34%) | 0.612 (6.6%) | |
| Tmax (h)† | Plasma | 1.33 (0.58) | nc |
| Blood | 1.33 (0.58) | nc |
*
Geometric means (% CV).
†
Arithmetic means (SD).
‡
AUCt ratio determined using time-matched AUCt values. CV, coefficient of variation; nc, not calculated; SD, standard deviation.