Table 1.

Number of subjects per treatment arm with PK and PD measurements (receptor occupancy and viral load) available in studies A4001002 and A4001007 (preliminary)

		Number of individuals (n = 88)
Study	Dose	PK	Receptor occupancy	Viral load
Healthy Volunteers (n = 63)	Placebo	–	8	–
	3 mg b.i.d.	5	5	–
	10 mg b.i.d.	5	5	–
	25 mg b.i.d.	9	9	–
	100 mg b.i.d.	9	9	–
	300 mg b.i.d.	9	–	–
	600 mg q.d.	18	–	–
	Total	55	36
Patients (n = 25)	Placebo	–	8	8
	25 mg q.d.	9*	8	8
	100 mg b.i.d.	8	8	7†
	Total	17	24	23

^*One patient had PK measurements only on day 1 and no receptor occupancy measurements.

^†One patient was excluded from viral load analysis because he did not meet the inclusion criteria.