Table 10.

Median baseline and changes from baseline in lipid parameters (study 2)

	Total cholesterol (median; mg dl−1)		HDL-cholesterol (median; mg dl−1)		LDL-cholesterol (median; mg dl−1)		Triglycerides (median; mg dl−1)
Dose	Baseline	Change from baseline	Baseline	Change from baseline	Baseline	Change from baseline	Baseline	Change from baseline
25 mg b.i.d.	160	4	44	0	99	7	84	−11
100 mg b.i.d.	169	1	55	−7	96	7	77	−10
300 mg b.i.d.	172	10	53	−4	91	15	95	−1
600 mg q.d. (cohort 3)	159	19	42	4	98	17	86	−8
600 mg q.d. (cohort 5)	149	14	49	2	80	16	89	−8
Placebo	200	−3	45	−1	131	−6	104	9