Table 6.
Statistical analysis of AUC12, Cmax and Tmax (study 3)
| Maraviroc dose | Comparison | AUC12 ratio % (95% CI) | Cmax ratio % (95% CI) | Tmax difference (95% CI) |
|---|---|---|---|---|
| 300 mg b.i.d. | Day 7/day 1* | 121 (106, 140) | 114 (93.2, 140) | 0.19 (−0.26, 0.63) |
| 600 mg b.i.d. | Day 14/day 7† | 237 (210, 267) | 224 (181, 277) | 0.00 (−0.22, 0.22) |
| 600 mg b.i.d. | Day 7/day 1* | 120 (104, 138) | 107 (87.5, 132) | 0.25 (−0.19, 0.69) |
| 900 mg b.i.d. | Day 14/day 7† | 152 (135, 171) | 138 (112, 171) | 0.00 (−0.22, 0.22) |
| 900 mg q.d. | Day 7/day 1* | 109 (95.7, 125) | 98.3 (81.1, 119) | 0.28 (−0.14, 0.70) |
| 1200 mg q.d. | Day 14/day 7† | 159 (142, 178) | 152 (125, 186) | −0.17 (−0.38, 0.04) |
*
The day 7/day 1 ratio shows the accumulation for the first dose with time.
†
The day 14/day 7 ratio shows the increase in exposure following the increase in dose, at steady state. CI, confidence interval.