Table 7.

Maraviroc effects on debrisoquine and cortisol metabolism (study 2)

Maraviroc dose	Assessment	Debrisoquine/4-OH-debrisoquine ratio	6β-OH-cortisol/cortisol ratio
Placebo	Baseline	0.96	4.90
	On treatment	0.85	4.55
25 mg b.i.d.	Baseline	0.86	7.01
	On treatment	0.72	6.03
100 mg b.i.d.	Baseline	0.63	4.09
	On treatment	0.65	3.75
300 mg b.i.d.	Baseline	1.52	3.80
	On treatment	1.13	3.90
600 mg q.d. (cohort 3)*	Baseline	nd	4.31
	On treatment	nd	5.48
600 mg q.d. (cohort 5)	Baseline	1.23	3.99
	On treatment	4.11	4.78

^*Results for cohort 3 are from day 7 instead of day 9. nd, no data.