Table 8.

Treatment-related adverse events in study 1

	Cohort A					Cohort B
	Placebo n = 12	1 mg n = 9	10 mg n = 9	100 mg n = 9	900 mg n = 9	Placebo n = 12	3 mg n = 9	30 mg n = 9	300 mg n = 9	1200 mg n = 9
Number of subjects with >1 Adverse event*	2	0	0	1	6	2	0	0	1	8
Abdominal pain	0	0	0	1	0	2	0	0	0	0
Asthenia	2	0	0	0	5	1	0	0	1	5
Headache	0	0	0	0	0	0	0	0	1	3
Hot flushes	0	0	0	0	0	0	0	0	0	2
Postural hypotension	0	0	0	0	0	0	0	0	0	4
Dry mouth	0	0	0	0	0	0	0	0	0	2
Dizziness	0	0	0	0	1	0	0	0	0	2
Abnormal vision	0	0	0	0	2	0	0	0	0	2

^*Table shows adverse events that were reported by more than one subject in any treatment group.