Table 3.
Parameter estimates for final QT–concentration model
| Model parameter | Estimate | 95% CI* |
|---|---|---|
| Structural model | ||
| Intercept (ms) | 398 | 391–403 |
| Sex (women) | 0.0166 | −0.000489–0.0364 |
| QT correction factor | 0.324 | 0.309–0.338 |
| Slope (concentration, μs ml ng−1) | 0.970 | −0.571–2.48 |
| Statistical model | Estimate | CV% |
| Intersubject variability (intercept) | 178 | 3.35 |
| Intersubject variability (correction factor) | 0.00287 | 16.5 |
| Intersubject variability (slope) | 5.41 | 240 |
| Interoccasion variability (intercept) | 13.4 | 0.920 |
| Residual intrasubject variability | 73.6 | 2.16 |
*
CIs derived from nonparametric bootstrap methods.