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. 2008 Apr 30;3(4):e2074. doi: 10.1371/journal.pone.0002074

Figure 1. Interactions between the dNTP substrate and RT.

Figure 1

A. Representation of the active site highlighting fingers subdomain residues involved in binding of the incoming nucleotide or AZT resistance. B. Detailed view of the interactions between the Lys65 residue, the incoming nucleotide and the catalytic metal ions. Metal ion coordination is depicted with a dashed purple line, hydrogen bonds with an orange line. Figures were generated from the published HIV-1 RT ternary structure (1rtd) [4] using the UCSF Chimera package [50].