Figure 1.

Viral infection of allergen-sensitized mice increases AHR and inflammatory cytokines in the lung. A: AHR of mice sensitized to CRA, infected with RSV, or in a combined model. *P = 0.0189 when compared to CRA and 0.0043 when compared to RSV. The dashed line represents AHR of naïve mice. We also measured amounts of IFN-γ (B) *P = 0.0139 when compared to CRA, IL-13 (C) *P = 0.0001 when compared to CRA and 0.0025 when compared to RSV, CCL3 (D) *P = 0.0394 when compared to CRA. E: CCL5 *P = 0.0260 when compared to CRA. F: H&E staining of lung sections showing representative airways of CRA, RSV, and CRA/RSV mice. n = five mice/group/experiment, data are pooled from three experiments.