Table 1.
Semiquantitative Assessment of Levels of TJ Protein Immunoreactivity Performed (n = 5 Serial Sections) Utilizing a Scale System Ranging from 0 to 3
| Control SCID (n = 3) | HIVE SCID (n = 7) | Control human cases (n = 2) | HIVE human cases (n = 4) | |
|---|---|---|---|---|
| CLD5-pT207 | 0 | 3 | 0.5 | 3 |
| OCC-pT382 | 0 | 1 | N/A | N/A |
| OCC-pS507 | 0 | 2 | 1 | 3 |
| Total CLD5 | 3 | 1.5* | 3 | 1* |
| Total OCC | 3 | 1* | 3 | 1* |
Scores of 0 = no positive staining in five ×20 fields (1.0 mm2 each); 1 = weak staining in less than 25% of microvessels; 2 = strong staining in 30 to 60% of microvessels; 3 = strong staining in more than 70% of microvessels.
*
Fragmented staining for TJ proteins was seen in HIVE human cases and HIVE mice.