Figure 4.

(A) Stereo view of the superposition of C_α backbone structures of DPCK from E. coli (blue) and H. influenzae (red). Residues at the trimer interface for the E. coli structure are marked with black dots. Every 25th residue of the E. coli structure is labeled. (B) Structure-based alignment of E. coli (EC) and H. influenzae (HI) DPCK sequences. Identical residues are shown in white lettering on a black background and conserved residues are shown in black lettering on a gray background. Secondary structure elements of the E. coli enzyme are marked above the alignment. Residues at the trimer interface for the E. coli structure are marked with asterisks below the alignment.