Figure 6.

Conformational entropy changes (ΔΔS) from (A,B) Pro to Ala, (C,D) Pro to Gly, and (E,F) Ala to Gly at the third and sixth positions, respectively. The values labeled HSC come from D’Aquino et al. (1996) and are similar in magnitude to the differences in available φ/ξ space obtained from simple hard-sphere collisions. The data shown represent the experimental values obtained for the difference in binding between each peptide pair and the different C-SH3 protein mutants (S170A, S170G, G171).