Table 1.
Summary of the solvent-exposed Ala/Gly mutants generated for both the Sem-5 C-SH3 domain and the Sos peptide
| Nomenclature | Sem-5 C-SH3 domain mutations | Location |
| G171 | Cys 209 → Ala (C209A; pseudo-WT) | |
| S170A | C209A, Ser 170 → Ala | RT loop |
| S170G | C209A, Ser 170 → Gly | RT loop |
| Nomenclature | Sos peptide variants |
| SosY | Ac-V0P1P2P3V4P5P6R7R8R9Y10-amide (wild type) |
| SosY-P3A | Ac-VPPAVPPRRRY-amide (Pro 3 → Ala) |
| Sosy-P3G | Ac-VPPGVPPRRRY-amide (Pro 3 → Gly) |
| SosY-P6A | Ac-VPPPVPARRRY-amide (Pro 6 → Ala) |
| SosY-P6G | Ac-VPPPVPGRRRY-amide (Pro 6 → Gly) |