Table 4B.

Percentage PPII ( P_PPII)^aat substituted position with Gly

Mutation	Position 3	Position 6	Averagea
P → Gb	9.6%	9.5%	9.6%
A → Gc	8%	16%	12%
P → Ad	10.1%	7.5%	8.8%

^aP_PPII = 1/[1 + K_conf,P(Gly)].

^bK_conf,P(Gly) = (1 − xz)/(xz/Ω − 1), where x is the ratio K_bind(Pro)/K_bind(Gly), Ω is the ratio K_conf,P(Gly)/K_conf,P(Pro) = 26.72 (see text), and z is the contribution of proline cis/trans isomerization (1 + 0.064; see text).

^cK_conf,P(Gly) = (1 − x)/(x/Ω − 1), where x is the ratio K_bind(Ala)/ K_bind(Gly) and Ω is the ratio K_conf,P(Ala)/K_conf,P(Gly) = 3.4 (see text).

^dK_conf,P(Gly) = Ω K_conf,P(Ala)^e, where Ω is the ratio K_conf,P(Ala)/ K_conf,P(Gly) = 3.4 (see text).

^e Determined as described in Table 4A.