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Schematic view of the MalE31 structure. The mutated residues at positions 32 and 33 (top left) occur in an αβ turn at an exposed position in the amino-terminal domain. Positions 13, 14, 38, and 63 located in the N-domain correspond to mutations affecting maltose transport (see text). The bound maltose substrate (middle) is located in a deep cleft between the amino- and carboxy-terminal domains.
