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Docked structure of Z-Phe-Arg-AMC (red) in falcipain-3 and falcipain-2. Connolly surfaces of only binding pockets are shown. L84 and L172 in falcipain-2 are colored yellow while Y93 and P181 in falcipain-3 are rendered blue. Z-benzyloxycarbonyl; AMC-7-amino-4-methyl coumarin.