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. 1999 Oct 26;96(22):12855–12859. doi: 10.1073/pnas.96.22.12855

Figure 1.

Figure 1

Prevention of MBP68–82-induced EAE by SR 57746A. (A) Effects on clinical severity. (B) Effects on EAE-induced weight loss. Lewis rats were immunized with 100 μg MBP68–82 in CFA on day 0 and given SR 57746A daily by oral route from day 0 until the end of the experiment. Weight loss was documented as the weight relative to that of day 1. Values are means ± SEM for 10 rats. ●, MBP68–82 + vehicle; ■, MBP68–82 + SR 57746A 10 mg/kg; ▴, MBP68–82 + SR 57746A 3 mg/kg; ▾, MBP68–82 + SR 57746A 1 mg/kg; ⧫, CFA + vehicle.