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Protective doses in EAE correlated with those required for the inhibition of TNF-α secretion. Groups of five rats were treated by oral route with SR 57746A at the indicated doses or with the vehicle only (dotted line) 1 h before LPS (1 mg/kg, i.p.). TNF-α was measured in plasma 1.5 h after LPS administration. ∗∗, P < 0.01/vehicle-treated rats.
