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. 1999 Oct 26;96(22):12860–12865. doi: 10.1073/pnas.96.22.12860

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Copyright © 1999, The National Academy of Sciences

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Restoration of functional BZ-modulated and synaptic GABA_A receptors in cultured cortical γ3^tg/γ2^0/0 neurons. (A) Representative recordings illustrating the effect of flunitrazepam (1 μM) on GABA-evoked currents (GABA 1 μM, 2 s) recorded from γ2^+/+, γ2^0/0, and γ3^tg/γ2^0/0 cortical neurons (18 days in vitro). (B) Relative frequency of GABAergic mIPSCs in cortical neurons cultured from γ2^+/+, γ2^0/0, and γ3^tg/γ2^0/0 embryos. GABAergic mIPSCs were identified based on current decay kinetics and pharmacological sensitivity (9). The input frequency was reduced to 33 ± 13.1% of γ2^+/+ in γ2^0/0 neurons and restored to 67 ± 8.9% by overexpression of the γ3 subunit in γ3^tg/γ2^0/0 neurons. Error bars, standard error.