Table 1.
Neurological deficit score
| Treatment | No. with score
|
n | Mean score | ||||
|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |||
| DMSO (0.4%) | 0 | 1 | 3 | 2 | 0 | 6 | 2.2 ± 0.3 |
| PD98059 (200 μM) | 3 | 3 | 1 | 0 | 0 | 7 | 0.7 ± 0.3* |
Neurological scoring was determined after 2 h of MCA occlusion and 72 h of reperfusion in mice treated with 200 μM PD98059 (n = 7) or vehicle (n = 6). The numeral abbreviations are as follows: 0, normal motor function; 1, flexion of contralateral torso and forelimb upon lifting of the animal by the tail; 2, circling to the contralateral side but normal posture at rest; 3, leaning to contralateral side at rest; and 4, no spontaneous motor activity. Mean scores are given ± SEM; *, P < 0.05. The data were analyzed by Mann–Whitney U test.