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. 1997 Aug 5;94(16):8818–8823. doi: 10.1073/pnas.94.16.8818

Figure 3.

Figure 3

Survival of DA neurons in the SN of 6-OHDA lesioned rats. The animals received intrastriatal Ad injections followed by 6-OHDA 6 days later. Three weeks after 6-OHDA injection, animals were sacrificed for TH immunohistochemistry. The number of TH+ cell bodies present in the SN at the coordinates AP −4.8, −5.3, and −5.8 mm from bregma (three or four sections per region of each animal) was determined. The values reported are means ± SEM for 6–11 rats per group and are expressed as percentages of TH+ cell counts in the contralateral nonlesioned SN. The survival of DA neurons is significantly higher in animals injected with Ad-GDNF (□) than with Ad-βGal (▪) or than in animals that received 6-OHDA alone (○). ∗∗, P < 0.01 versus 6-OHDA alone; φ, P < 0.01 and ‡, P < 0.001 versus Ad-βGal.