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. 1997 Aug 19;94(17):9261–9266. doi: 10.1073/pnas.94.17.9261

Table 5.

Codon differences between VH domains of fusion phage clones and closest germ-lines genes

Clone Closest germline V gene VH Family Positions where codons differ
Closest germ-line D/J genes Positions where codons differ
Silent Expressed Silent Expressed
B73 DP-47 VH3 88, 89 49, 94 D21-10/JH6C 99 95, 96, 97, 98, 100, 100A, C, D, E, H, I, J
E13 DP-47 VH3 8, 73, 88, 89 94 D21-10/JH6C 99 95, 96, 97, 98, 100, 100A, C, D, E, H, I, J, K
E26 DP-47 VH3 42, 80, 81, 88, 89 30, 40, 52, 55, 94 D21-10/JH6C 99 95, 96, 97, 98, 100, 100A, C, D, E, H, I, J
C55 DP-47 VH3 89 87, 94 D4-b/JH4b 99 97, 98, 100, 100A, C
G71 DP-88 VH1 9 DA5-a/JH3b 97 98, 100, 100A, B
F2 DP-35 VH3 15, 71, 73, 88 11, 13, 16, 32, 54, 84 DA5-a/JH6b 95 96, 97, 98, 99, 100B, C, D

The closest germ-line sequences were obtained from a scan of the IMGT databases (5). The codon positions correspond to the scale used in Fig. 3; silent differences indicate there is no change, and expressed differences indicate there is a change in the encoded amino acid.