Figure 3.

Transfer of short term T cell lines from mice immunized with L144/R147 but not control peptide protects animals from disease. T cell lines were restimulated in vitro with L144/R147 or PLP-(139–151) (LNC from mice immunized with L144/R147) or with Nase-(101–120) or PCC-(92–104) [LNC from mice immunized with Nase-(101–120) or PCC-(92–104), respectively] and transferred i.v. (5 × 10⁶ cells per mouse) at the time of immunization to induce active disease with a low dose of PLP-(178–191) (10–50 μg per mouse).