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. 2008 Mar 13;9:32. doi: 10.1186/1471-2202-9-32

Table 4.

Genes differentially expressed 24h or 28d following carrageenan injection and known to be involved in pain.

GenBank Description Name P-value Cluster Selection criteria References
1. Membrane receptors and their ligands

NM_022225 5-hydroxytryptamine (serotonin) receptor 1b Htr1b 0.0005 A w [48]; [49]
NM_012685 vasoactive intestinal peptide receptor 1 Vipr1 0.0017 A w [50]
U30290 galanin receptor 1 Galr1 0.0095 B w [51]
BI395810 neuropeptide y receptor y1 Npy1r 0.0085 B w [52]
NM_017155 adenosine a1 receptor Adora1 0.0034 E w [53]
U28430 5-hydroxytryptamine (serotonin) receptor 3a Htr3a 0.0002 E w [48]
NM_022695 neurotensin receptor 2 Ntsr2 0.0001 E w [54]
BF412731 prodynorphin Pdyn 0.0000 F w, z [55]
M11596 calcitonin-related polypeptide, beta Calcb 0.0000 G w, z [56]
BG376217 glutamate receptor, ionotropic, ampa1 (alpha 1) Gria1 0.0073 H w [57]
NM_017011 glutamate receptor, metabotropic 1 Grm1 0.0000 H w [37]
NM_012870 neuropeptide y receptor y5 Npy5r 0.0021 H w, z [32]; [58]

2. Ion channels and regulator of ion homeostasis

AI010839 potassium large conductance calcium-activated channel, subfamily m, alpha member 1 Kcnma1 0.0050 A w [59]
M34052 potassium voltage gated channel, shaw-related subfamily, member 2 Kcnc2 0.0014 B w [59]
AI717104 potassium inwardly-rectifying channel subfamily J member 14 Kcnj14 0.0003 B w [59]
NM_032073 potassium voltage-gated channel, subfamily q, member 1 Kcnq1 0.0019 B w [59]
AI137995 sodium channel, voltage-gated, type iv, beta Scn4b 0.0087 B w [60]
NM_012618 s100 calcium-binding protein a4 S100a4 0.0066 E w [61]
NM_053587 s100 calcium binding protein a9 (calgranulin b) S100a9 0.0002 F w, z [62; 62]
X04280 calbindin 1 Calb1 0.0016 G w, z [63]

3. cAMP and adenylate cyclase cascade

M12672 guanine nucleotide binding protein, alpha inhibiting 2 Gnai2 0.0028 A y [64]
U39572 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide Pik4ca 0.0096 A w [65]
NM_053926 phosphatidylinositol-4-phosphate 5-kinase, type ii, alpha Pip5k2a 0.0067 A w [65]
BF410504 g-protein-coupled receptor gpr34 GPR34 0.0000 D y [66]
NM_053456 phospholipase c-like 1 Plcl1 0.0000 D w [67]
BM386789 regulator of g-protein signaling 1 Rgs1 0.0071 E w [68]
BI281632 regulator of g-protein signalling 10 Rgs10 0.0008 F w [68]
NM_017142 adenylyl cyclase 8 Adcy8 0.0098 G y [35]
NM_134386 g protein-coupled receptor associated sorting protein 1 GASP1 0.0071 G w, y [69]
BF565001 phosphodiesterase 4d Pde4d 0.0053 G w [70]
AY043246 regulator of g-protein signaling 2 Rgs2 0.0003 G w [38]
NM_017214 regulator of g-protein signaling 4 Rgs4 0.0074 G w [38]
NM_080411 g protein-coupled receptor 83 Gpr83 0.0052 H y [66]

4. MAPK cascade

BG664160 mitogen-activated protein kinase kinase kinase kinase 3 Map4k3 0.0027 A w [34]
AF092450 mitogen activated protein kinase 8 interacting protein Mapk8i p 0.0001 A w [34]
NM_133545 protein tyrosine phosphatase 2e Ptpn21 0.0011 A w [71]
AI102620 mitogen activated protein kinase kinase kinase 1 Map3k1 0.0027 B w [33]
BI290864 mitogen activated protein kinase kinase kinase 3 Map3k3 0.0098 B w [33]
AJ271834 protein phosphatase 1b, magnesium dependent, beta isoform Ppm1b 0.0000 B w [72]
BE113127 protein phosphatase 3, catalytic subunit, alpha isoform Ppp3ca 0.0029 B w [72]
AA924620 rab40b, member ras oncogene family Rab40b 0.0068 B y [73]
AI233712 protein phosphatase 1d magnesium-dependent, delta isoform Ppm1d 0.0011 D y [72]
AI104546 protein tyrosine phosphatase 4a3 Ptp4a3 0.0067 E y [72]
NM_130403 protein phosphatase 1, regulatory (inhibitor) subunit 14a Ppp1r1 4a 0.0000 E y [72]
AI411122 rab1, member ras oncogene family Rab1 0.0013 H y [73]
BM384841 rab15, member ras onocogene family Rab15 0.0044 H y [73]

5. Growth factors and related proteins

NM_012513 brain derived neurotrophic factor BDNF 0.0067 B w, z [43] [42]
XM_231739 IGF2 binding protein 3 Igf2bp3 0.0091 D w [74]
NM_013104 IGF binding protein 6 Igfbp6 0.0020 E w [74]
BE102996 neurotrophic tyrosine kinase, receptor, type 2 Ntrk2 0.0042 E w [13]
U02315 neuregulin 1 Nrg1 0.0022 G w, z [75]

6. Arachidonic acid cascade and mediators of inflammation

NM_138547 3-alpha-hydroxysteroid dehydrogenase 0.0055 C w [76]
U03389 prostaglandin-endoperoxide synthase 2 cox2 0.0019 D w [77]
J04488 prostaglandin d2 synthase Ptgds 0.0017 E w [78]
NM_017020 interleukin 6 receptor Il6ra 0.0030 F w [76]
AA851740 interleukin 6 signal transducer Il6st 0.0025 F w [76]
NM_133551 phospholipase a2, group 4a Pla2g4a 0.0024 F w [79]
AA893169 tissue inhibitor of metalloproteinase 3 Timp3 0.0060 F w [9]

7. Others

NM_012823 annexin a3 Anxa3 0.0026 A w,z [14]
BI281979 microtubule-associated proteins 1b Map1lc 3b 0.0076 A y, z [15]
AB011679 tubulin, beta 5 Tubb5 0.0019 A y [17]
NM_023974 synaptoporin Synpr 0.0009 B y, z [16]
NM_012551 early growth response 1 Egr1 0.0037 B w [29]
BI294912 proteasome subunit, alpha type 3 Psma3 0.0020 D w [80]
BI283657 chaperonin subunit 4 (delta) Cct4 0.0001 F y [18]
BG372598 neural cell adhesion molecule 1 Ncam1 0.0045 F w,z [81]
NM_012755 fyn proto-oncogene Fyn 0.0010 E w [19]

For cluster description see Result and Figure 3.

Selection criteria:

w – involved in pain-related pathways.

y – interact with or regulate protein involved in pain perception.

z- expression level is altered in different model of pain.