Table 4.
Genes differentially expressed 24h or 28d following carrageenan injection and known to be involved in pain.
| GenBank | Description | Name | P-value | Cluster | Selection criteria | References |
| 1. Membrane receptors and their ligands | ||||||
| NM_022225 | 5-hydroxytryptamine (serotonin) receptor 1b | Htr1b | 0.0005 | A | w | [48]; [49] |
| NM_012685 | vasoactive intestinal peptide receptor 1 | Vipr1 | 0.0017 | A | w | [50] |
| U30290 | galanin receptor 1 | Galr1 | 0.0095 | B | w | [51] |
| BI395810 | neuropeptide y receptor y1 | Npy1r | 0.0085 | B | w | [52] |
| NM_017155 | adenosine a1 receptor | Adora1 | 0.0034 | E | w | [53] |
| U28430 | 5-hydroxytryptamine (serotonin) receptor 3a | Htr3a | 0.0002 | E | w | [48] |
| NM_022695 | neurotensin receptor 2 | Ntsr2 | 0.0001 | E | w | [54] |
| BF412731 | prodynorphin | Pdyn | 0.0000 | F | w, z | [55] |
| M11596 | calcitonin-related polypeptide, beta | Calcb | 0.0000 | G | w, z | [56] |
| BG376217 | glutamate receptor, ionotropic, ampa1 (alpha 1) | Gria1 | 0.0073 | H | w | [57] |
| NM_017011 | glutamate receptor, metabotropic 1 | Grm1 | 0.0000 | H | w | [37] |
| NM_012870 | neuropeptide y receptor y5 | Npy5r | 0.0021 | H | w, z | [32]; [58] |
| 2. Ion channels and regulator of ion homeostasis | ||||||
| AI010839 | potassium large conductance calcium-activated channel, subfamily m, alpha member 1 | Kcnma1 | 0.0050 | A | w | [59] |
| M34052 | potassium voltage gated channel, shaw-related subfamily, member 2 | Kcnc2 | 0.0014 | B | w | [59] |
| AI717104 | potassium inwardly-rectifying channel subfamily J member 14 | Kcnj14 | 0.0003 | B | w | [59] |
| NM_032073 | potassium voltage-gated channel, subfamily q, member 1 | Kcnq1 | 0.0019 | B | w | [59] |
| AI137995 | sodium channel, voltage-gated, type iv, beta | Scn4b | 0.0087 | B | w | [60] |
| NM_012618 | s100 calcium-binding protein a4 | S100a4 | 0.0066 | E | w | [61] |
| NM_053587 | s100 calcium binding protein a9 (calgranulin b) | S100a9 | 0.0002 | F | w, z | [62; 62] |
| X04280 | calbindin 1 | Calb1 | 0.0016 | G | w, z | [63] |
| 3. cAMP and adenylate cyclase cascade | ||||||
| M12672 | guanine nucleotide binding protein, alpha inhibiting 2 | Gnai2 | 0.0028 | A | y | [64] |
| U39572 | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | Pik4ca | 0.0096 | A | w | [65] |
| NM_053926 | phosphatidylinositol-4-phosphate 5-kinase, type ii, alpha | Pip5k2a | 0.0067 | A | w | [65] |
| BF410504 | g-protein-coupled receptor gpr34 | GPR34 | 0.0000 | D | y | [66] |
| NM_053456 | phospholipase c-like 1 | Plcl1 | 0.0000 | D | w | [67] |
| BM386789 | regulator of g-protein signaling 1 | Rgs1 | 0.0071 | E | w | [68] |
| BI281632 | regulator of g-protein signalling 10 | Rgs10 | 0.0008 | F | w | [68] |
| NM_017142 | adenylyl cyclase 8 | Adcy8 | 0.0098 | G | y | [35] |
| NM_134386 | g protein-coupled receptor associated sorting protein 1 | GASP1 | 0.0071 | G | w, y | [69] |
| BF565001 | phosphodiesterase 4d | Pde4d | 0.0053 | G | w | [70] |
| AY043246 | regulator of g-protein signaling 2 | Rgs2 | 0.0003 | G | w | [38] |
| NM_017214 | regulator of g-protein signaling 4 | Rgs4 | 0.0074 | G | w | [38] |
| NM_080411 | g protein-coupled receptor 83 | Gpr83 | 0.0052 | H | y | [66] |
| 4. MAPK cascade | ||||||
| BG664160 | mitogen-activated protein kinase kinase kinase kinase 3 | Map4k3 | 0.0027 | A | w | [34] |
| AF092450 | mitogen activated protein kinase 8 interacting protein | Mapk8i p | 0.0001 | A | w | [34] |
| NM_133545 | protein tyrosine phosphatase 2e | Ptpn21 | 0.0011 | A | w | [71] |
| AI102620 | mitogen activated protein kinase kinase kinase 1 | Map3k1 | 0.0027 | B | w | [33] |
| BI290864 | mitogen activated protein kinase kinase kinase 3 | Map3k3 | 0.0098 | B | w | [33] |
| AJ271834 | protein phosphatase 1b, magnesium dependent, beta isoform | Ppm1b | 0.0000 | B | w | [72] |
| BE113127 | protein phosphatase 3, catalytic subunit, alpha isoform | Ppp3ca | 0.0029 | B | w | [72] |
| AA924620 | rab40b, member ras oncogene family | Rab40b | 0.0068 | B | y | [73] |
| AI233712 | protein phosphatase 1d magnesium-dependent, delta isoform | Ppm1d | 0.0011 | D | y | [72] |
| AI104546 | protein tyrosine phosphatase 4a3 | Ptp4a3 | 0.0067 | E | y | [72] |
| NM_130403 | protein phosphatase 1, regulatory (inhibitor) subunit 14a | Ppp1r1 4a | 0.0000 | E | y | [72] |
| AI411122 | rab1, member ras oncogene family | Rab1 | 0.0013 | H | y | [73] |
| BM384841 | rab15, member ras onocogene family | Rab15 | 0.0044 | H | y | [73] |
| 5. Growth factors and related proteins | ||||||
| NM_012513 | brain derived neurotrophic factor | BDNF | 0.0067 | B | w, z | [43] [42] |
| XM_231739 | IGF2 binding protein 3 | Igf2bp3 | 0.0091 | D | w | [74] |
| NM_013104 | IGF binding protein 6 | Igfbp6 | 0.0020 | E | w | [74] |
| BE102996 | neurotrophic tyrosine kinase, receptor, type 2 | Ntrk2 | 0.0042 | E | w | [13] |
| U02315 | neuregulin 1 | Nrg1 | 0.0022 | G | w, z | [75] |
| 6. Arachidonic acid cascade and mediators of inflammation | ||||||
| NM_138547 | 3-alpha-hydroxysteroid dehydrogenase | 0.0055 | C | w | [76] | |
| U03389 | prostaglandin-endoperoxide synthase 2 | cox2 | 0.0019 | D | w | [77] |
| J04488 | prostaglandin d2 synthase | Ptgds | 0.0017 | E | w | [78] |
| NM_017020 | interleukin 6 receptor | Il6ra | 0.0030 | F | w | [76] |
| AA851740 | interleukin 6 signal transducer | Il6st | 0.0025 | F | w | [76] |
| NM_133551 | phospholipase a2, group 4a | Pla2g4a | 0.0024 | F | w | [79] |
| AA893169 | tissue inhibitor of metalloproteinase 3 | Timp3 | 0.0060 | F | w | [9] |
| 7. Others | ||||||
| NM_012823 | annexin a3 | Anxa3 | 0.0026 | A | w,z | [14] |
| BI281979 | microtubule-associated proteins 1b | Map1lc 3b | 0.0076 | A | y, z | [15] |
| AB011679 | tubulin, beta 5 | Tubb5 | 0.0019 | A | y | [17] |
| NM_023974 | synaptoporin | Synpr | 0.0009 | B | y, z | [16] |
| NM_012551 | early growth response 1 | Egr1 | 0.0037 | B | w | [29] |
| BI294912 | proteasome subunit, alpha type 3 | Psma3 | 0.0020 | D | w | [80] |
| BI283657 | chaperonin subunit 4 (delta) | Cct4 | 0.0001 | F | y | [18] |
| BG372598 | neural cell adhesion molecule 1 | Ncam1 | 0.0045 | F | w,z | [81] |
| NM_012755 | fyn proto-oncogene | Fyn | 0.0010 | E | w | [19] |
For cluster description see Result and Figure 3.
Selection criteria:
w – involved in pain-related pathways.
y – interact with or regulate protein involved in pain perception.
z- expression level is altered in different model of pain.