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. 2008 Apr 21;181(2):335–350. doi: 10.1083/jcb.200705060

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Copyright © 2008, The Rockefeller University Press

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Figure 9. — Differential migratory response of WT-ASMase vs. ASMase^S508A cells to cisplatin treatment. MCF-7 cells stably overexpressing WT-ASMase or ASMase^S508A were treated with either cisplatin or DMSO. (A) Cell migration was analyzed by wound-healing assay as described under Materials and methods. Wound size was measured at 0, 24, and 48 h after scratching a confluent monolayer of cells. (B) Cells overexpressing ezrin T567D or a control (pCB6) plasmid were subjected to the wound-healing migration assay. Cell migration was assessed by measuring wound size at 0, 24, and 48 h. Results shown are representative of three independent experiments (*, P < 0.05).