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. 2002 May 15;541(Pt 1):187–199. doi: 10.1113/jphysiol.2001.013418

Figure 3. Effect of BDM on maximal isometric force in rabbit psoas (5 °C) and soleus (15 °C) myofibrils.

Figure 3

A, experimental tracing from a psoas myofibril subjected to exposure to 2 mm BDM by rapid solution change at the plateau of an isometric contraction. Relative force in the presence of 2 mm BDM: 0.71; kTR in control conditions and in the presence of 2 mm BDM: 2.3 s−1 and 1.6 s−1, respectively. Force transients following application and removal of BDM: rates of force decrease and increase were 1.9 s−1 and 1.8 s−1, respectively. B, experimental tracing from a soleus myofibril subjected to 10 mm BDM. Relative force in the presence of 10 mm BDM: 0.74; kactiv in control conditions 0.8 s−1. Force transients following application and removal of BDM: rates of force decrease and increase were 0.8 s−1 and 0.7 s−1, respectively. C, relation between [BDM] and maximal isometric force in rabbit psoas (5 °C, •) and soleus myofibrils (15 °C, ○). Hyperbolic fit of each data set (continuous lines) gave half-maximal effect of force depression in fast and slow myofibrils at [BDM] of 3.3 ± 2.8 mm and 6.9 ± 4.5 mm, respectively.