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. 1999 Oct 26;96(22):12911–12916. doi: 10.1073/pnas.96.22.12911

Figure 3.

Figure 3

Potassium-evoked GABA-mediated IPSCs are much reduced in GAD65−/− mice. (A) (Top) GABA-mediated, K+-eIPSCs recorded from a RGC of a WT mouse at a holding potential of 0 mV. The GABA release was evoked by puffing 60 mM K+ on the cell body layer of the amacrine cells. Puff durations varied from 20 msec to 200 msec. The puffing was repeated three times at each duration. (Middle) GABA-mediated eIPSCs recorded from a RGC of a GAD65−/− mouse. (Bottom) The puffing durations. (B) Frequency of GABA-mediated eIPSCs recorded from RGCs of WT (n = 5) and GAD65−/− mice (n = 7) at various puff durations. Frequency was derived as the number of IPSCs recorded over a 1-sec period after the puff. (C) The total charge carried by the GABA-mediated eIPSCs recorded from RGCs of WT and GAD65−/− mice at various puff durations. (D) Average amplitude of GABA-mediated eIPSCs recorded from RGCs of WT and GAD65−/− mice at various puff durations.