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Stimulation by anti-CD40 mAb markedly up-regulated Fas expression on B cells from both NZB/W F1 and BALB/c mice. Splenic lymphocytes from 2-month-old NZB/W F1 and BALB/c mice were cultured with anti-CD40 mAb for 3 days, and Fas expression was examined by two-color flow cytometry.
