Figure 3. Ileal contractile responses to nicotinic agonists in α5–/– (n = 6) and wild-type (n = 20) mice.

Ileal contractile responses are represented as a percentage of response to bethanechol at a concentration of 10 μm. The nicotinic agonists were used at concentrations of 10 μm for cytisine, dimethylphenylpiperazinium iodide (DMPP) and nicotine and 0.1 μm for epibatidine. *P < 0.05, **P < 0.01, Bonferroni multiple comparison tests, in α5–/– mice compared to littermate wild-type animals. Vertical bars indicate s.e.m.