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ER-binding and inhibition of lipid peroxidation of the compounds.
| Compound | IC50 for ER Binding (nM) | IC50 for Inhibition of Lipid Peroxidation (µM) | ||
|---|---|---|---|---|
| ERα | ERβ | FTC Method | TBARS Method | |
| 1,3,5(10)-Estratriene-3,17β-diol (E2) | 1.3 | 0.7 | 11.9 | 3.9 |
| 17β-butoxy-1,3,5(10)-estratriene-3-ol (17OBu-E2, 1) | 12.3 | 15.5 | 4.1 | 2.7 |
| 10β-Hydroxy-17β-butoxy-1,4-estradiene-3-one (17OBu-E2Q, 2) | > 10,000 | > 10,000 | n.i. | n.i. |
