Table 1.

Inhibition of amyloid-induced decrease in MTT reduction

Treatment	Inhibition, % of control
150 nM Aβ1-42	100
+ Phloretin, 30 μM	2
+ Phloridizin, 1 mM, 24 hr	87
+ Dipyramidole, 5 μM, 1 hr	72
+ 4-Aminopyridine, 1 mM, 24 hr	85
+ Tetraethylammonium, 4 mM, 1 hr	114
+ Dendrodotoxin, 280 nM, 24 hr	100
+ Phenolphthalein 50 μM, 1 hr	−47
+ Exifone, 30 μM, 24 hr	25

PC12 cells were treated for 24 hr with 150 nM Aβ1-42, and compounds were added prior to MTT for the time indicated. Inhibition of amyloid-induced decrease in MTT reduction is calculated as % of control: 100% = ΔOD 595 nm (MTT reduction in control cells − MTT reduction in amyloid treated cells). Negative values represent reduction higher than in control cells.