Figure 8.
Survival curves for FALS mice treated with continuous intraperitoneal infusion of saline or 15 mg/kg per day C3 carboxyfullerene via implanted mini-osmotic pumps for 2 months, starting at age 2 months. Animals treated with carboxyfullerene had increased survival (P = 0.023 by t test). Three surgical deaths occurred during pump implantation, two in the C3-treated group (after 1 month of treatment, before symptom onset), and one in the control group (with initial pump placement). All procedures conformed to Washington University institutional guidelines for animal welfare.