Figure 4.

A putative capping enzyme from C. elegans. The amino acid sequence of the C. elegans C03D6.2 gene product from residues 273 to 573 is aligned with the sequences of the guanylyltransferases of Sc. pombe (spo), S. cerevisiae (sce), C. albicans (cal), and Chlorella virus PBCV-1 (chv). Gaps in the sequence are indicated by dashes (-). Amino acids conserved in all five proteins are denoted by asterisks. The six nucleotidyltransferase motifs are shown in shaded boxes. Residues in proximity to the GTP moiety in the PBCV-1 cocrystal are indicated by arrowheads.