Table 1.

Response of neurons to gp120

	% neurons failing to respond to gp120	Ca rise, nM
Vehicle	9.6	2,814  ±  211
Corticosterone	0.0	6,585  ±  162*
Estradiol	35.7	3,999  ±  220

The percentage of neurons that failed to respond to gp120 with a mobilization of free cytosolic calcium concentrations was measured. Glucocorticoid treatment, on the average, significantly reduced the percentage of neurons that were unresponsive to gp120, whereas estradiol had the opposite effect (P < 0.001 by χ² analysis). Responsiveness consisted of an increase in cytosolic calcium concentrations after gp120, 200 pM, administration (n = 135, 148, and 378 for vehicle, 100 nM corticosterone, and 100 nM estradiol, respectively). The extent of calcium mobilization in neurons that responded to gp120 with a calcium rise was measured. Numbers represent data (mean ± SEM) taken from those neurons that were responsive to gp120 (i.e., those that were not included above). 

^*P < 0.001 when compared to vehicle by Newman–Keuls post-hoc test after one-way ANOVA.