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. Author manuscript; available in PMC: 2008 Apr 17.
Published in final edited form as: Epilepsia. 2007 Nov 19;49(3):386–392. doi: 10.1111/j.1528-1167.2007.01416.x

Table 2.

Evaluating genetic association studies

(a) Have the authors employed an accepted, valid definition of the phenotype adequate enough to reproduce the study?
(b) Have the authors measured the phenotype appropriately?
(c) Were suitable controls (matched at least for age, sex, race) used for comparison of allele frequency?
(d) What was the probability of replication, given the sample size of the replication study and the strength of association in the original study?
(e) Were markers of comparable location and informativeness used in this study?
(f) Was there consideration of possible genetic heterogeneity based on symptoms or race?