Table 4.

Relative Process Rates for Proposed Alternative Cycles for Glutamate Trafficking

Process	Cycle for Functional Glutamate Trafficking
	GGOC		GGMC		GGCC
	PN	A	PN	A	PN	A
cGS	N/A	1/2	N/A	1/2	N/A	1/2
cPAG	1/2	N/A	1/2	N/A	1/2	N/A
cN	1/2	−1/2	1/2	−1/2	1/2	−1/2
cBCAT	0	0	0	0	0	0
cALAT	0	0	0	0	0	0
mGDH	−1/2	1/2	−1/2	1/2	−1/2	1/2
mN	−1/2	1/2	−1/2	1/2	−1/2	1/2
mPDH	1/2	0	1/2	0	0	1/2
mCS	1/2	0	1/2	0	0	1/2
mAH	1/2	0	1/2	0	1/2	0
mIDH	1/2	0	1/2	0	1/2	0
mOGDH	1/2	0	0	1/2	0	1/2
mSCS	1/2	0	0	1/2	0	1/2
mSDH	1/2	0	0	1/2	0	1/2
mFH	1/2	0	0	1/2	0	1/2
mMDH	1/2	0	1/2	0	0	1/2
mNDK	1/2	0	0	1/2	0	1/2
pmGLAST(Glu)	N/A	1	N/A	1	N/A	1
pmSNAT3(Gln)	N/A	1/2	N/A	1/2	N/A	1/2
pmSNAT1(Gln)	−1/2	N/A	−1/2	N/A	−1/2	N/A
pmGLUT(Gluc)	1/4	0	1/4	0	0	1/4
pmNaCT(OG)	−1/2	1/2	0	0	0	0
pmNaCT(Mal)	0	0	−1/2	1/2	0	0
pmNaCT(Cit)	0	0	0	0	−1/2	1/2
pmNHE	−1	1 1/2	−1	1 1/2	−1 1/2	2
pmKCNK	1	1/3	1	1/3	2/3	2/3
mmGC	−1/2	1/2	−1/2	1/2	−1/2	1/2
mmMCT(Pyr)	1/2	0	1/2	0	0	1/2
mmPiC	6 3/4	5/8	4 1/4	3 1/8	5/8	6 3/4
mmAAC	6 1/4	1 1/8	3 3/4	3 5/8	1/8	7 1/4
mmOGC	−1/2	1/2	0	0	0	0
mmCIC	0	0	0	0	−1/2	1/2
mmDIC	1/2	−1/2	1/2	−1/2	1/2	−1/2
cG	1/4	0	1/4	0	0	1/4
MAS	1/2	0	1/2	0	0	1/2
ET1	2	1/2	1 1/2	1	0	2 1/2
ET2	1/2	0	0	1/2	0	1/2
mmATPase	5 3/4	1 1/8	3 3/4	3 1/8	1/8	6 3/4
pmNaKATPase	1/2	2/3	1/2	2/3	1/3	5/6
pmExoATPase	1	N/A	1	N/A	1	N/A
cATPase	4 1/4	−1/24	1 3/4	2 11/24	−2 5/24	6 5/12

Prefixes: cytosolic (c), mitochondrial (m), plasma membrane (pm), and mitochondrial membrane (mm).