Figure 2.
Effects of DPT on head twitch behavior in mice (filled circles), antagonism of these effects by 1.0 mg/kg (unfilled inverted triangles) and 3.0 mg/kg (filled inverted triangle) of the selective 5-HT1A antagonist WAY100635, and by 0.01 mg/kg of the selective 5-HT2A antagonist M100907 (unfilled triangles). All points represent the mean ± SEM (N = 6 mice per group), and any points without error bars indicate instances in which the SEM is encompassed by the data point. Abscissa: Dose of DPT expressed as mg/kg on a log scale. Ordinate: Mean head twitches recorded over a 10 minute observation period.