Figure 5.
Involvement of JAK-2 in triggering delayed cardioprotection by Gd. Rats were pretreated with the JAK inhibitor AG-490 (3 mg/kg) or saline 15 min before Gd treatment (20 μmol/kg) and resistance to injury from IR determined 24–120 hours later. Infarct size and recovery of post-ischemic left ventricular developed pressure was determined after 30 minutes of regional ischemia and 120 minutes of reperfusion. Values are mean ± SD. * = P < 0.05 vs drug-free control.