Table 1.
Hemodynamic values for Gd dose-response studies. Values are mean ± SD, n = 6/group. Hearts subjected to 30 minutes regional ischemia followed by 2 hours of reperfusion.
| BASELINE
|
15 min POST DRUG
|
15min ISCHEMIA
|
2hr REPERFUSION
|
|||||
|---|---|---|---|---|---|---|---|---|
| Heart rate, beats/min | MAP, mmHg | Heart rate, beats/min | MAP, mmHg | Heart rate, beats/min | MAP, mmHg | Heart rate, beats/min | MAP, mmHg | |
| Drug-free control | 353 ± 3 | 128 ± 6 | - | - | 370 ± 17 | 127 ± 6 | 347 ± 9 | 96 ± 6* |
| Gd (1 μmol/kg) | 354 ± 5 | 131 ± 4 | 360 ± 7 | 127 ± 5 | 366 ± 7 | 120 ± 3* | 362 ± 6 | 80 ± 9* |
| Gd (5 μmol/kg) | 377 ± 12 | 134 ± 5 | 378 ± 14 | 126 ± 7 | 377 ± 12 | 119 ± 8* | 353 ± 11 | 81 ± 6* |
| Gd (20 μmol/kg) | 387 ± 11 | 117 ± 5 | 382 ± 9 | 100 ± 4* | 382 ± 8 | 90 ± 5* | 372 ± 8 | 66 ± 4* |
| Gd (30 μmol/kg) | 373 ± 11 | 126 ± 3 | 377 ± 8 | 102 ± 4* | 380 ± 7 | 89 ± 5* | 363 ± 8 | 68 ± 5* |
| Gd (40 μmol/kg) | 380 ± 4 | 134 ± 2 | 376 ± 9 | 104 ± 5* | 380 ± 5 | 88 ± 2* | 358 ± 3* | 69 ± 3* |
| Gd (100 μmol/kg) | 364 ± 13 | 130 ± 3 | 360 ± 13 | 98 ± 2* | 358 ± 14 | 94 ± 4* | 352 ± 13 | 51 ± 7* |
*
= P < 0.05, vs baseline group. MAP = mean arterial pressure.