Table 1.

Clinical features of pediatric ALL cases evaluated for c-Myc protein stabilization

Patient	Age (years)	Gender	Diagnosis	Outcome	c-Myc half-life (min)	FISH for c-myc
1	6	M	Pre-B ALL	CCR	91.2	IS
2	3	F	Pre-B ALL	BM Relapse→death	57.8	2, c-myc; 2 CEP8
3	2	F	Pre-B ALL	CCR	56.4	2–4, c-myc; 2–4 CEP8a
4	16	M	T-cell ALL	N/A	44.6	2, c-myc; 2 CEP8
5	2	M	Pre-B ALL	CCR	31.4	2, c-myc; 2 CEP8
6	4	M	T-cell ALL	CCR	17.6	IS
Control	N/A	N/A	—	—	19.6b	IS

Abbreviations: ALL, acute lymphoblastic leukemia; BM relapse, bone marrow relapse; CCR, continuous complete remission; F, female; FISH, fluorescent in situ hybridization; IS, insufficient sample to perform FISH analysis; M, male; N/A, clinical information not available.

Notes: Age at diagnosis is listed in years. Immunophenotype was determined by flow cytometry at diagnosis for each patient. Measured c-Myc half-life is listed in minutes.

^aTwenty nine of the 100 cells had four signals for c-myc and four for CEP8, indicating tetrasomy 8, 10/100 cells showed trisomy 8 with three signals for c-myc and three for CEP8, 57/100 showed normal two c-myc, two CEP8 and 4/100 showed one c-myc and two CEP8.

^bRepresentative result of three samples tested (c-Myc half-life range: 17–21 min). (FISH) was performed on 100 interphase cells for each sample.