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Mammalian proteins known to regulate c-Myc protein stability and their S. cerevisiae orthologs
| Mammalian protein | Effect on c-Myc protein stability | S. cerevisiae orthologs |
|---|---|---|
| ERK kinase | Stabilizing (6) | Kss1 |
| GSK3β kinase | Destabilizing (9) | Rim11 |
| Pin1 isomerase | Destabilizing (11) | Ess1 |
| PP2A C subunit | Destabilizing (11, 23) | Ppph21 |
| PP2A B subunit (B′ type) | Destabilizing (23) | Rts1 |
| F-box hCdc4 (Fbw7) | Destabilizing (12, 13) | Cdc4 |
| F-box Skp2 | Destabilizing (18, 38) | Grr1 |
