Table 3.
Genotype counts and ORs for LOX 1.2 in the ADVANCE study combining both sets of cases and controls
| Recessive | Additive | Dominant | |||||||
| Genotype | Cases N (%) | Controls N (%)) | minimal model | fully adjusted model | minimal model | fully adjusted model | minimal model | fully adjusted model | |
| LOX1.2 |
OR CI |
OR CI |
OR CI |
OR CI |
OR CI |
OR CI |
|||
| White | GG | 1034 (86) | 842 (80) | ||||||
| GC | 154 (13) | 194 (19) | 1.44 0.6–3.6 |
1.59, 0.6–4.0 |
0.75** 0.6–0.9 |
0.76* 0.6–0.95 |
0.69** 0.6–0.9 |
0.7** 0.6–0.9 |
|
| CC | 12 (1) | 9 (1) | |||||||
| Black/AA | GG | 65 (68) | 201 (61) | ||||||
| GC | 30 (31) | 118 (36) | 0.25 0.01–1.4 |
0.23 0.01–1.3 |
0.8 0.5–1.3 |
0.77 0.47–1.2 |
0.85 0.5–1.4 |
0.82 0.5–1.4 |
|
| CC | 1 (1) | 12 (3) | |||||||
| Hispanic | GG | 96 (89) | 73 (89) | ||||||
| GC | 12 (11) | 9 (11) | 1 NA |
1 NA |
1.05 0.4–2.9 |
1.18 0.4–3.4 |
1.05 0.4–2.9 |
1.18 0.4–3.4 |
|
| CC | 0 (0) | 0 (0) | |||||||
| E. Asian | GG | 90 (77) | 66 (64) | ||||||
| GC | 23 (20) | 33 (32) | 1.02 0.2–4.9 |
1.94 0.2–4.8 |
0.61 0.4–1.0 |
0.56* 0.3–0.98 |
0.49* 0.3–0.9 |
0.45* 0.2–0.97 |
|
| CC | 4 (3) | 4 (4) | |||||||
| Mix. Hisp. | GG | 72 (86) | 48 (89) | ||||||
| GC | 11 (13) | 6 (11) | 3E+09 NA |
8E+08 NA |
1.66 0.6–5.5 |
1.51 0.5–5.3 |
1.64 0.5–5.6 |
1.51 0.46–5.3 |
|
| CC | 1 (1) | 0 (0) | |||||||
| Mix. other | GG | 150 (74) | 92 (79) | ||||||
| GC | 53 (26) | 21 (18) |
0* NA |
0* NA |
1.32 0.8–2.3 |
1.28 0.73–2.3 |
1.6 0.9–3.0 |
1.56 0.8–3.0 |
|
| CC | 0 (0) | 3 (3) | |||||||
| All | GG | 1507 (83) | 1322 (76) | ||||||
| GC | 283 (16) | 381 (22) | 0.8 0.41–1.5 |
0.8 0.41–1.5 |
0.8** 0.7–0.9 |
0.8* 0.7–0.95 |
0.77** 0.6–0.93 |
0.78** 0.7–0.94 |
|
| CC | 18 (1) | 28 (2) | |||||||
OR = Odds ratio, ref = reference group, NA = unable to compute, All P values < 0.05 in bold, * P < 0.05, ** P < 0.01.
† combined analyses adjusted for race/ethnic group and case/control set
Minimal model adjusted for age, sex. Fully adjusted analyses adjusted for age, sex, BMI, smoking status, hypertension, diabetes, high cholesterol, "admixed" strata further adjusted for proportion of white, black, Hispanic, E. Asian ancestry derived from STRUCTURE analyses. Non-stratified analyses further adjusted by race/ethnic group and cases/control status.