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. 2008 Apr 22;118(5):1877–1889. doi: 10.1172/JCI34308

Figure 9. Opposite effects of Pin1 overexpression on peripheral neuropathies of WT tau and Tg P301L tau mice.

Figure 9

Analysis of semithin sections of the sciatic nerves revealed presence of degenerating axons (arrows) often engulfed by macrophages (C, inset) in 18-month-old Tg WT tau mice (C) but not in the age-matched Pin1/tau double-Tg mice (D), non-Tg WT (A), or Pin1 Tg mice (B). On the contrary, few neuronal lesions were detected in sciatic nerves (E) of 7-month-old Tg P301L tau mice, while overexpression of Pin1 and P301L tau caused massive neurodegeneration in the sciatic nerves of the age-matched double-Tg mice. (F). Arrowheads point to demyelinated axon, and arrows point to macrophages clearing myelin debris. Scale bars: 20 μm.