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. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234

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© 2007 Al-Ramahi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) Anti-dAtx2 immunofluorescence (red) in ventral ganglion neurons expressing different Ataxin-1 transgenes and CD8-GFP (green) with the ok107-GAL4 driver. Nuclear Lamin (white) is also shown. (A) Control neurons show no nuclear dAtx2. (B) Neurons expressing Ataxin-1 with only 2Q (SCA1^2Q) present no nuclear dAtx2. (C) Neurons expressing wild type human Ataxin-1 with 30Q (SCA1^30Q) fail to show nuclear dAtx2 as well. (D) Neurons expressing expanded Ataxin-1[82Q] (SCA1^82Q) present nuclear dAtx2.

Genotypes: (A) UAS-CD8:GFP/+; +; ok107-GAL4/+. (B) UAS-CD8:GFP/+; UAS-SCA1^2Q [F14]/+; ok107-GAL4/+ (C) UAS-SCA1^30Q [F1]/yw; UAS-CD8:GFP/+; ok107-GAL4/+. (D) UAS-CD8:GFP/+; UAS-SCA1^82Q [M6]/+; ok107-GAL4/+.